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According to the literature available, sexual dysfunction and changes in libido performance were not reported side effects associated with treatment with Depakote. Tell your health care provider about any negative side effects from prescription drugs. I accept the Terms and Privacy Policy. Before taking valproic acid, tell your doctor and pharmacist if you are allergic to valproic acid, any other medications, or any of the ingredients in the type of valproic acid that has been prescribed for you. Tell your doctor if you are not able to eat or drink as you normally do. Valproate should not be administered to a woman of childbearing potential unless other medications have failed to provide adequate symptom control or are otherwise unacceptable Depakote Warnings and Precautions 5. Serious or fatal hepatotoxicity may be preceded by non-specific symptoms such as malaise, weakness, lethargy, facial edema, anorexia, and vomiting. The initial dose was mg daily. Estrogen-Containing Hormonal Contraceptives Estrogen-containing hormonal contraceptives may increase the clearance of valproate, which may result in decreased concentration of valproate and potentially increased seizure frequency. Valproic acid may help to control your condition but will not cure it. However, healthcare providers should not rely totally on serum biochemistry since these tests may not be abnormal in all instances, but should also consider the results of careful interim medical history and physical examination. Do not take more or less of it or take it more often than prescribed by your doctor. Can children take Depakote? DailyMed will deliver this notification to your desktop, Web browser, or e-mail depending on the RSS Reader you select to use. The increased risk of suicidal thoughts or behavior with AEDs was observed as early as one week after starting drug treatment with AEDs and persisted for the duration of treatment assessed. Common side effects of Depakote may include tremor, somnolence, and diplopia or double vision. Article continues below Concerned about Bipolar Disorder? If you develop abdominal painnausea, vomiting, and a stomach that is tender to the touch, call immediately. Evidence suggests that folic acid supplementation prior to conception and during the first trimester of pregnancy decreases the risk for congenital neural tube defects in the general population [see Use in Specific Populations 8. Women who are pregnant must not take Depakote or Depakene to prevent migraine headaches. Depakote is contraindicated in patients with known urea cycle disorders [see Warnings and Precautions 5. Depaokte clinical studies are conducted under Depakpte varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be eDpakote compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice. Sometimes it is not safe to use certain medications at the same time. All rights reserved. This adverse reaction is not due to a pharmacokinetic interaction. Inflammation of your pancreas that can cause death. The estimates cited apply primarily to patients who are not taking drugs that affect hepatic metabolizing enzyme systems. Pancreatitis Cases of life-threatening pancreatitis have been reported in both children and adults receiving valproate. A good correlation has not been established between daily dose, serum concentrations, and therapeutic effect. Article continues below Concerned about Bipolar Disorder? In clinical trials, there were 2 cases of pancreatitis without alternative etiology in 2, patients, representing 1, patient-years experience. Stopping suddenly may cause a serious, life-threatening type of seizure. Some young people have thoughts about suicide when first taking Depakote. In animal studies, valproate administration during pregnancy resulted in fetal structural malformations similar to those seen in humans and neurobehavioral deficits in the offspring at clinically relevant doses [see Data Animal ]. The risk of getting this serious liver damage is more likely to happen within the first 6 months of treatment. AbbVie is providing these links to you only as a convenience, and the inclusion of any link does not imply the endorsement of the linked site by AbbVie. Table 5. There have been reports of hepatic failure and clotting abnormalities in offspring of women who used valproate during pregnancy [see Use in Specific Populations 8. In a study of adjunctive therapy for complex partial seizures in which patients were receiving either carbamazepine or phenytoin in addition to valproate, no adjustment of carbamazepine or phenytoin dosage was needed [see Clinical Studies Brand names. Depakote is approved by the U. The concomitant use of valproate and clonazepam may induce absence status in patients with a history of absence type seizures. For other cognitive domains evaluated at 6 years, no adverse cognitive effects of continued exposure to an AED including valproate via breast milk were observed. Depakote side Depakote in more detail. In some patients with somnolence approximately one-halfthere was associated reduced nutritional intake and weight loss. A: Severe drowsiness is a side effect of Depakote. You are about to enter a site that is for U. Birth defects, such as spina bifida, and developmental problems, such as lowered IQ, have been reported. Clonazepam The concomitant use of valproate and clonazepam may induce absence status in patients with a history of absence type seizures. Q: I take generic Depakote at night for bipolar condition. The information available for Depakote indicates that an effective form of birth control should be used while being treated with this medication and you should not start using Depakote without speaking to your doctor if you are pregnant. Valproate polytherapy with other AEDs has been associated with an increased frequency of congenital malformations compared with AED monotherapy. Chemically it is designated as sodium hydrogen bis 2-propylpentanoate. Join NAMI. Depakote Sprinkle Capsules may be swallowed whole, or they may be opened and the contents may be sprinkled on a small amount of soft food, such as applesauce or pudding. Let your doctor know if these side effects are severe or if they aren't going away. If you develop abdominal painnausea, vomiting, and a stomach that is tender to the touch, call immediately. The relationship between plasma concentration and clinical response is not well documented. Risk Summary For use in prophylaxis of migraine headaches, valproate is contraindicated in women who are pregnant and in women of childbearing potential who are not using effective contraception [see Contraindications 4 ]. If you are pregnant, plan to become pregnant, or are breast-feeding If you drink alcohol or use illegal drugs How Should I Take Valproate? Q: Can Depakote or Resperidine cause false protein in urine tests? Valproate can cause fetal harm when administered to a pregnant woman. In contrast, drugs that are inhibitors of cytochrome P isozymes, e. Read this Medication Guide before you start taking Depakote or Depakene and each time you get a refill. In animal studies, oral administration of valproate at clinically relevant doses resulted in adverse reproductive effects in males [see Nonclinical Toxicology Valproic Acid pronounced as val proe' ik. Ask your doctor or pharmacist for more information. Doctors often recommend a bone density test to identify which people need treatment for Depa,ote loss. Keep this medication in the container it came in, tightly closed, and out of reach of children. EDpakote A. Since patients were being titrated off another antiepilepsy drug during the first portion Depakotee the trial, it is not possible, in many cases, to determine whether the following adverse reactions can be ascribed to Depakote alone, or the combination of valproate and Dwpakote antiepilepsy drugs. Mothers continued AED therapy during the breastfeeding period. Depakote is a medication known as an anticonvulsant that is used to treat the manic symptoms of bipolar disorder. Depakote FAQs. This rebate form is not available to individuals who are paying cash for their prescription or who are receiving prescription reimbursement under a state or federally funded insurance program. Alternative treatment for the underlying medical condition should be initiated as clinically indicated [see Boxed Warning ]. Swallow the regular capsules, delayed-release capsule, and extended-release tablets whole; do not split, chew, or crush them. You are leaving the AbbVie website and connecting to the Track It! If you have diabetes and your doctor has told you to test your urine for ketones, tell the doctor that you are taking valproic acid. Randomized patients were to be followed for a total of 16 weeks. Tell your healthcare provider if you cannot swallow Depakote or Depakene whole. If you have been experiencing a change in libido, you may want to contact your health care provider to determine the cause and best treatment option available. Valproate was not mutagenic in an in vitro bacterial assay Ames testdid not produce dominant lethal effects in mice, and did not increase chromosome aberration frequency in an in vivo cytogenetic study in rats. Depakote has no habit-forming potential, but it is not recommended that you discontinue use of the drug before talking with your doctor, as withdrawal symptoms can occur. Dermatologic: Hair texture changes, hair color changes, photosensitivity, erythema multiforme, toxic epidermal necrolysis, nail and nail bed disorders, and Stevens-Johnson syndrome. Stopping a seizure medicine suddenly in a patient who has epilepsy can cause seizures that will not stop status epilepticus. Depakote Sprinkle Capsules may be swallowed whole, or broken open and sprinkled on a small amount of soft food like applesauce or pudding. Tell your health care provider about any negative side effects from prescription drugs. Although there are no efficacy data that specifically Deppakote longer-term antimanic treatment with Depakotte, the safety of Depakote in long-term use is Dfpakote by data from record reviews involving approximately patients treated with Depakote for greater than 3 months. Food and Drug Administration. Free E-newsletter Subscribe to Housecall Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Depakote is also approved to treat bipolar disorder as well as for prevention of migraine headaches. Valproate syrup: Measure with a dosing spoon or oral syringe that you can get from your pharmacy. High ammonia levels in your blood: feeling tired, vomiting, changes in mental status. Do not crush, chew or split tablets. The mean 4-week migraine headache rates during the treatment phase, adjusted for differences in baseline rates, were 4. With input from you, your health care provider will assess how long you will need to take the medicine. Do not take two doses at one time. It is important to note that some of the side effects listed above particularly changes in platelets, liver or pancreas problems, and suicidal thoughts may continue to occur or worsen if you continue taking the medication. Explore Apps. The drug should be discontinued immediately in the presence of significant hepatic dysfunction, suspected or apparent. Before taking valproic acid, tell your doctor and pharmacist if you are allergic to valproic acid, any other medications, or any of the ingredients in the type of valproic acid that has been prescribed for you. Do not let anyone else take your medication. Consideration should be given to stopping valproate in patients who develop hypothermia, which may be manifested by a variety of clinical abnormalities including lethargy, confusion, coma, and significant alterations in other major organ systems such as the cardiovascular and respiratory systems. Pediatric Clinical Trials Depakote was studied in seven pediatric clinical trials. Because the women in this study were exposed to antiepileptic drugs throughout pregnancy, whether the risk for decreased IQ was related to a particular time period during pregnancy could not be assessed. It is recommended that patients receiving Depakote be monitored for blood counts and coagulation parameters prior to planned surgery and during pregnancy [see Use in Specific Populations 8. Talk to your healthcare provider if you have questions. How should this medicine be used? If the total daily dose exceeds mg, it should be given in divided doses.
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Depakote is used to treat various types of seizure disorders. It is sometimes used together with other seizure medications. It is also used to treat the manic phase of bipolar disorders (manic-depressive illness), and to prevent migraine headaches. Depakote affects chemicals in the body that may be involved in causing seizures.


Use Depakote as directed by your doctor.

  • Take Depakote by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Swallow Depakote whole. Do not break, crush, or chew before swallowing.
  • Drink plenty of water while you are taking Depakote. Your dose may need to be changed if you do not get enough fluids each day.
  • Do not stop taking Depakote suddenly, especially if you are taking Depakote to prevent seizures. Suddenly stopping Depakote may cause severe seizures to occur. If you need to stop Depakote, your doctor will gradually lower your dose.
  • Taking Depakote at the same time each day will help you remember to take it.
  • Continue to take Depakote even if you feel well. Do not miss any dose. Depakote works best when there is a constant level of it in your body.
  • If you miss a dose of Depakote, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Depakote.


Store Depakote between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Depakote out of the reach of children and away from pets.


Active Ingredient: Divalproex.

Do NOT use Depakote if:

  • you are allergic to any ingredient in Depakote
  • you have liver problems or a urea cycle disorder.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Depakote. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of alcohol abuse, liver problems, metabolic disease, blood disease, HIV infection, cytomegalovirus (CMV) infection, high blood levels of ammonia or glutamine, low body temperature, low levels of albumin, brain problems (eg, organic brain disease), mental retardation, inflammation of the pancreas, kidney problems, or low levels of white blood cells, or if you are scheduled for surgery
  • if you have a history of ornithine transcarbamylase deficiency or unexplained coma
  • if you have a family history of urea cycle disorders or unexplained infant deaths
  • if you have a history of mental or mood problems (eg, depression), or suicidal thoughts or actions
  • if you take any other medicine for seizures.

Some medicines may interact with Depakote. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Benzodiazepines (eg, diazepam), carbamazepine, erythromycin, felbamate, fluoxetine, guanfacine, isoniazid, ketoconazole, risperidone, or salicylates (eg, aspirin) because the risk of serious side effects of Depakote, including changes in vision or other vision problems, clumsiness or unsteadiness, drowsiness, nausea, or vomiting, may be increased
  • Clonazepam because the risk of seizures may be increased
  • Topiramate because the risk of high ammonium levels, brain problems, or an unusual drop in body temperature may be increased
  • Acyclovir, cancer medicines, carbapenem antibiotics (eg, ertapenem, imipenem, meropenem), cholestyramine, hydantoins (eg, phenytoin), mefloquine, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), oral contraceptives (eg, birth control pills), or rifampin because they may decrease Depakote's effectiveness
  • Anticoagulants (eg, warfarin), barbiturates (eg, phenobarbital), ethosuximide, lamotrigine, methylphenidate, primidone, tolbutamide, tricyclic antidepressants (eg, amitriptyline), or zidovudine because the risk of their side effects may be increased by Depakote.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Depakote may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Depakote may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Depakote with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Depakote; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Inflammation of the pancreas is a potentially life-threatening illness associated with Depakote. Symptoms include stomach pain, vomiting, or loss of appetite. Contact your doctor at once if any of these symptoms occur.
  • Patients who take Depakote may be at increased risk for suicidal thoughts or actions. The risk may be greater in patients who have had suicidal thoughts or actions in the past. Patients who have bipolar (manic-depressive) illness may also have an increased risk for suicidal thoughts or actions. Watch patients who take Depakote closely. Contact the doctor at once if new, worsened, or sudden symptoms, such as depressed mood; anxious, restless, irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.
  • Depakote may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Tell your doctor or dentist that you take Depakote before you receive any medical or dental care, emergency care, or surgery.
  • Diabetes patients - Depakote may cause the results of some tests for urine ketones to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.
  • Depakote may increase the ammonia levels in your blood. Contact your doctor right away if you experience unexplained sluggishness and vomiting or mental changes.
  • Depakote may cause an unusual drop in body temperature (hypothermia). Symptoms may include confusion, lack of energy, loss of coordination, shivering, slow heartbeat, slow or shallow breathing, slurred speech, or unusual drowsiness. Contact your doctor right away if you have any of these symptoms.
  • Depakote may interfere with certain lab tests, including thyroid function. Be sure your doctor and lab personnel know you are taking Depakote
  • Lab tests, including complete blood cell counts, blood ammonia levels, and liver function, may be performed while you use Depakote. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Depakote with caution in the elderly; they may be more sensitive to its effects, especially drowsiness.
  • Depakote should be used with extreme caution in children younger than 10 years old; safety and effectiveness in these children have not been confirmed. Children younger 2 years may be at increased risk of serious liver problems.
  • Pregnancy and breast-feeding: Depakote has been shown to cause harm to the fetus. Use an effective form of birth control while you take Depakote. If you think you may be pregnant or if you wish to become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Depakote while you are pregnant. Depakote is found in breast milk. Do not breastfeed while you are taking Depakote.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Change in appetite; constipation; diarrhea; dizziness; drowsiness; hair loss; headache; indigestion; nausea; stomach cramps or pain; trouble sleeping; vomiting; weakness; weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal thinking; change in menstrual period; changes in behavior; chest pain; confusion; dark, tarry, or bloody stools; dark urine; difficulty speaking; difficulty urinating or other urination problems; extreme tiredness; fast or irregular heartbeat; hallucinations; hearing loss; involuntary movements of the arms and legs; involuntary movements or chewing movements of the face, jaw, mouth, or tongue; joint pain; lack of energy; loss of appetite; loss of coordination; loss of seizure control; memory loss; new or worsening mental or mood changes (eg, aggressiveness, agitation, anxiety, depression, exaggerated feeling of well-being, hostility, impulsiveness, inability to sit still, irritability, panic attacks, restlessness); nosebleed; pounding in the chest; red, swollen, blistered, or peeling skin; severe or persistent nausea, vomiting, or stomach pain; shortness of breath; suicidal thoughts or actions; swelling of the arms or legs; symptoms of infection (eg, fever, chills, sore throat); tremor; unusual bleeding or bruising; unusual weakness; vision changes or blurred vision; yellowing of the skin or eyes.

 This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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