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DPP-4 inhibitors The real interest in the pharmaceutical industry appears Januvia be in developing the orally-administered DPP-4 inhibitors. They can recommend strategies that make swallowing tablets easier. Januvia is Jxnuvia in development with two strengths of metformin and mg as combined tablets. Many people use Januvia without having any serious side effects. TrustScore 9. In the case that Januvia no longer works for you, your blood sugar level may become high. The maximum concentration it reaches is nM, with a half-life of There have been postmarketing reports of worsening renal function, including acute renal failure, sometimes requiring dialysis. AUC increases proportionally to dose increases. In a clinical studypeople took Januvia for 24 weeks. However, skin rashes can be a symptom of an allergic reaction to Januvia. Peripheral oedema occurred in 9. In this article, learn about how to prevent the condition by losing weight…. Contact afpserv aafp. The recommended dosage is 5 mg, once a day. The scale of the problem and the burden it will place on health care systems and society is immense, so new initiatives to halt the epidemic will receive a sympathetic hearing. Postmarketing cases of bullous pemphigoid requiring hospitalization have been reported with DPP-4 inhibitor use. A dosage adjustment is recommended in patients with moderate or severe renal impairment and in patients with end-stage renal disease requiring hemodialysis or peritoneal dialysis. This site is intended only for residents of the United States, its territories, and Puerto Rico. Stop taking Januvia and call your doctor if you have symptoms of pancreatitis : severe pain in your upper stomach spreading to your back, with or without vomiting. Controlling diabetes may also lessen your risk of a stroke or a heart attack. The incidence and rate of hypoglycemia based on all reports of symptomatic hypoglycemia were: Your doctor will ultimately prescribe the smallest dosage that provides the desired effect. These lists contain examples of more common side effects that can occur with Januvia or with metformin. AUC increases proportionally to dose increases. Other DPP 4 inhibitors are also likely to include combinations with metformin - the gold-standard first-line therapy with proven ability to reduce cardiovascular events. In people who took Januvia with the diabetes drug glimepiride, the rate of hypoglycemia was Immediately report to your doctor your reaction to what you consume to raise your sugar level. Furthermore, they do not tackle the need to arrest progress of disease. This hormone increases the amount of sugar in your blood. You can also ask your pharmacist for information on how to dispose of your medication. Summary A new DPP-4 inhibitor class of oral anti-diabetic medicines, working by the novel mechanism of incretin enhancement, is poised to revolutionise the management of Type 2 diabetes. October 17, Januvia All inclusive service No hidden fees. Hypoglycemia rates in patients receiving sitagliptin were similar to those in patients receiving placebo or metformin alone, with no incidents of severe hypoglycemia 1 — 3 ; however, it is unknown whether sitagliptin will increase hypoglycemic events when combined with sulfonyl-ureas or insulin. Follow all directions on your prescription label and read all medication guides or instruction sheets. How do I buy Januvia online? Monthly newsletter. A clinical study looked at the health history of 71, people who took Januvia. If you have or had any kidney problems, let your doctor know right away. If you notice a rash on your skin, let your doctor know. Patients with moderate renal insufficiency creatinine clearance of 30 to 50 mL per minute [0. Januvia and alcohol. Your doctor will determine the best dosage to suit your needs. Your doctor shall determine which dose of Januvia you will be taking. The existence of Januvia case reports of kidney failure and hypersensitivity reactions is noted in the United States prescribing information, but a causative role for sitagliptin has not been established. There have been postmarketing reports of worsening renal function, including acute renal failure, sometimes requiring dialysis. Januvia is only approved to treat type 2 diabetes. If you have had pancreatitis inflammation of the pancreasit is not known if you have a higher chance of getting it while taking JANUVIA. Before and while you take Januvia, your doctor will give you blood tests to see how your kidneys are working. Many medications can affect the levels of your blood sugar, which makes sugar levels hard to control. Januvia is a medication that is used with a proper diet and exercise program and possibly with other medications to control high blood sugar. In addition, higher levels of GLP-1 cause your body to release less of a hormone called glucagon. Summary A new DPP-4 inhibitor class of oral anti-diabetic medicines, working by the novel mechanism of incretin enhancement, is poised to revolutionise the management of Type 2 diabetes. So with less glucagon in your body, your blood sugar levels decrease. Email Alerts Don't miss a single issue. This includes prescription and over-the-counter medicines, vitaminsand herbal products. Byetta normally involves twice-daily injections and achieves satisfactory reductions in HbA1c and weight, but is associated with a high incidence of nausea affecting up to 50 per cent of users.

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Januvia Take this medication by mouth with or without a meal, ad broken by your doctor, true once Jnuvia. If you have or had any other problems, let your nose know right away. This date is there one year from the date they had the medication. In a week every study of influenza with type 2 diabetes, Januvia gelatinous A1C bowels 0. If you drink heavily on a few basis and have low blood sugar, your blood sugar level may drop even more.
The Galvus group responded faster, Jqnuvia less oedema and showed an improved lipid profile compared to the rosiglitazone group. Other interactions can increase the number of side effects or make them more Januvia. If a hypersensitivity reaction is observed or suspected, treatment should be discontinued. The healthy glucagon-insulin balance is lost resulting in both fasting and postprandial hyperglycaemia. This means that they work in similar ways in your body. If you have type 1 diabetes, talk with your doctor. More studies are needed. Studies have not evaluated the effects of sitagliptin on microvascular or macrovascular complications or mortality.
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Januvia
Active Ingredient: Sitagliptin
Januvia is used for treating type 2 diabetes in patients who cannot control blood sugar levels by diet and exercise alone.
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INDICATIONS

Januvia is used for treating type 2 diabetes in patients who cannot control blood sugar levels by diet and exercise alone. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicines. Januvia is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by increasing the amount of insulin released by your body, and decreasing the amount of sugar made by your body.

INSTRUCTIONS 

INDICATIONS

Januvia is used for treating type 2 diabetes in patients who cannot control blood sugar levels by diet and exercise alone. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicines. Januvia is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by increasing the amount of insulin released by your body, and decreasing the amount of sugar made by your body.

INSTRUCTIONS

Use Januvia as directed by your doctor.

  • Take Januvia by mouth with or without food.
  • Take Januvia on a regular schedule to get the most benefit from it.
  • Continue to take Januvia even if you feel well. Do not miss any doses.
  • If you miss a dose of Januvia, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Januvia.

STORAGE

Store Januvia at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Januvia out of the reach of children and away from pets.

MORE INFO:

Active Ingredient: Sitagliptin.

Do NOT use Januvia if:

  • you are allergic to any ingredient in Januvia
  • you have type 1 diabetes
  • you have high blood ketone levels (diabetic ketoacidosis).

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Januvia. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have kidney problems
  • if you have a history of inflammation of the pancreas (pancreatitis).

Some medicines may interact with Januvia. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Digoxin or sulfonylureas (eg, glipizide) because the risk of their side effects may be increased by Januvia.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Januvia may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Follow the diet and exercise program given to you by your health care provider. Proper diet, regular exercise, and regular blood sugar testing are important for best results with Januvia.
  • Check your blood sugar levels as directed by your doctor. If they are often higher or lower than they should be and you take Januvia exactly as prescribed, tell your doctor.
  • It may be harder to control your blood sugar during times of stress such as fever, infection, injury, or surgery. Talk with your doctor about how to control your blood sugar if any of these occur. Do not change the dose of your medicine without checking with your doctor.
  • Januvia usually does not cause low blood sugar. However, low blood sugar may occur when it is used along with certain other medicines for diabetes (eg, sulfonylureas). Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you hungrier. It is a good idea to carry a reliable source of glucose (eg, tablets, gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.
  • Lab tests, including fasting blood glucose, glycosylated hemoglobin, and kidney function, may be performed while you use Januvia. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Januvia with caution in the elderly; they may be more sensitive to its effects.
  • Januvia should be used with extreme caution in children younger 18 years; safety and effectiveness in these children have not been confirmed.
  • Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Januvia while you are pregnant. It is not known if Januvia is found in breast milk. If you are or will be breast-feeding while you use Januvia, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Diarrhea; headache; nausea; runny or stuffy nose; sore throat; upper respiratory infection; upset stomach.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); fever, chills, or persistent sore throat; red, blistered, swollen, or peeling skin; symptoms of pancreas inflammation (eg, severe stomach or back pain with nausea or vomiting, stomach tenderness or swelling, fast heartbeat, dizziness).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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